Back Pertussis-Toxin German Pertussis toxin English Toxina pertussis Spanish Tossina della pertosse Italian 百日咳毒素 Japanese Pertuzijski toksin Serbo-Croatian Toksin oslovskega kašlja Slovenian Pertussistoxin Swedish
| Pertuzijski toksin, podjedinica 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Kristalna struktura pertuzijskog toksina,[1] | |||||||||
| Identifikatori | |||||||||
| Simbol | Pertussis_S1 | ||||||||
| Pfam | PF02917 | ||||||||
| InterPro | IPR003898 | ||||||||
| SCOP | 1bcp | ||||||||
| SUPERFAMILY | 1bcp | ||||||||
| |||||||||
| Pertuzijski toksin, podjedinice 2 i 3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| Simbol | Pertussis_S2S3 | ||||||||
| Pfam | PF02918 | ||||||||
| InterPro | IPR003899 | ||||||||
| SCOP | 1bcp | ||||||||
| SUPERFAMILY | 1bcp | ||||||||
| |||||||||
| Pertuzijski toksin, podjedinica 4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| Simbol | Pertus-S4-tox | ||||||||
| Pfam | PF09275 | ||||||||
| InterPro | IPR015355 | ||||||||
| SCOP | 1prt | ||||||||
| SUPERFAMILY | 1prt | ||||||||
| |||||||||
| Pertuzijski toksin, podjedinica 5 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| Simbol | Pertus-S5-tox | ||||||||
| Pfam | PF09276 | ||||||||
| InterPro | IPR015356 | ||||||||
| SCOP | 1prt | ||||||||
| SUPERFAMILY | 1prt | ||||||||
| |||||||||
Pertuzijski toksin (PT) je proteinski egzotoksin AB5-tipa koji proizvodi bakterija Bordetella pertussis,[2] koja uzrokuje veliki kašalj. PT učestvuje u kolonizaciji respiratornog trakta i uspostavljanju infekcije.[3] Istraživanja sugeriraju da PT možda može da ima terapeutsku ulogu u tretiranju brojnih ljudskih bolesti, među kojima je hipertenzija,[4] viralna inhibicija,[5] i autoimunska inhibicija.[6][7][8]
- ^ Stein PE, Boodhoo A, Armstrong GD, Cockle SA, Klein MH, Read RJ (1994). „The crystal structure of pertussis toxin”. Structure. 2 (1): 45—57. PMID 8075982. doi:10.1016/S0969-2126(00)00007-1.
- ^ Ryan KJ; Ray CG, ур. (2004). Sherris Medical Microbiology (4th изд.). McGraw Hill. ISBN 0-8385-8529-9.
- ^ Carbonetti NH, Artamonova GV, Mays RM, Worthington ZE (2003). „Pertussis Toxin Plays an Early Role in Respiratory Tract Colonization by Bordetella pertussis”. Infect. Immun. 71 (11): 6358—66. PMC 219603
. PMID 14573656. doi:10.1128/IAI.71.11.6358-6366.2003.
- ^ Kost C, Herzer W, Li P, Jackson E (1999). „Pertussis toxin-sensitive G-proteins and regulation of blood pressure in the spontaneously hypertensive rat”. Clin Exp Pharmacol Physiol. 26 (5–6): 449—55. PMID 10386237. doi:10.1046/j.1440-1681.1999.03058.x.
- ^ Alfano M, Pushkarsky T, Poli G, Bukrinsky M (2000). „The B-Oligomer of Pertussis Toxin Inhibits Human Immunodeficiency Virus Type 1 Replication at Multiple Stages”. J Virol. 74 (18): 8767—70. PMC 116391 . PMID 10954581. doi:10.1128/JVI.74.18.8767-8770.2000.
- ^ Bagley K, Abdelwahab S, Tuskan R, Fouts T, Lewis G (2002). „Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway”. J Leukoc Biol. 72 (5): 962—9. PMID 12429718.
- ^ Locht C, Keith JM (1986). „Pertussis toxin gene: nucleotide sequence and genetic organization”. Science. 232 (4755): 1258—1264. PMID 3704651. doi:10.1126/science.3704651.
- ^ Rappuoli R, Nicosia A, Perugini M, Franzini C, Casagli MC, Borri MG, Antoni G, Almoni M, Neri P, Ratti G (1986). „Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication”. Proc. Natl. Acad. Sci. U.S.A. 83 (13): 4631—4635. PMC 323795 . PMID 2873570. doi:10.1073/pnas.83.13.4631.
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